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Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance

✍ Scribed by Mas, A.


Book ID
111746671
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
436 KB
Volume
19
Category
Article
ISSN
0261-4189

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## Abstract The K65R mutation in HIV‐1 reverse transcriptase (RT) can be selected by the RT inhibitors tenofovir (TDF), abacavir (ABC), and didanosine (DDI). Recently, in vitro studies have shown that K65R is selected in tissue culture more rapidly with subtype C than subtype B viruses. The prevale