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Role for the MOV10 RNA helicase in Polycomb-mediated repression of the INK4a tumor suppressor

✍ Scribed by Messaoudi-Aubert, Selma El; Nicholls, James; Maertens, Goedele N; Brookes, Sharon; Bernstein, Emily; Peters, Gordon

Book ID: 109965807
Publisher: Nature Publishing Group
Year: 2010
Tongue: English
Weight: 751 KB
Volume: 17
Category: Article
ISSN: 1545-9993
DOI: 10.1038/nsmb.1824

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## Abstract Granulosa cell tumors (GCTs) of the ovary are relatively rare and account for <5% of all ovarian cancers. The molecular pathogenesis of these tumors is not well understood. We tested the hypothesis that cyclin‐dependent kinase inhibitors, specifically the __in__hibitors of the cyclin‐de