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Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis

โœ Scribed by Benjamin C. Ling; Jianqiang Wu; Shyra J. Miller; Kelly R. Monk; Rania Shamekh; Tilat A. Rizvi; Gabrielle DeCourten-Myers; Kristine S. Vogel; Jeffrey E. DeClue; Nancy Ratner

Book ID
113523500
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
931 KB
Volume
7
Category
Article
ISSN
1535-6108

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Epidermal growth factor (EGF) and transforming growth factor-alpha (TGFo0 are two closely related peptides that interact with cell-surface epidermal growth factor receptors (EGFR) to induce receptor tyrosine phosphorylation and activation of intracellular signal-transduction pathways. EGF appears to