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Role and regulation of cyclooxygenase-2 during inflammation

✍ Scribed by Lee S Simon

Book ID
117016398
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
99 KB
Volume
106
Category
Article
ISSN
1555-7162

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Heparan sulfate is rapidly degraded by an endoglycosidase (heparanase) secreted by activated platelets. Since the cleavage and release of heparan sulfate would profoundly alter the local physiology of the endothelium, platelet heparanase activity should be tightly regulated. Consistent with this hyp