Physiologically based pharmacokinetic mo
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Trudy Rodgers; Malcolm Rowland
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Article
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2006
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John Wiley and Sons
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English
⚖ 269 KB
A key component of whole body physiologically based pharmacokinetic (WBPBPK) models is the tissue-to-plasma water partition coefficients (Kpu's). The predictability of Kpu values using mechanistically derived equations has been investigated for 7 very weak bases, 20 acids, 4 neutral drugs and 8 zwit