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Rodgers T, Rowland M. 2006. Physiologically-based Pharmacokinetic Modeling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci 95:1238–1257.

✍ Scribed by Trudy Rodgers; Malcolm Rowland


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
75 KB
Volume
96
Category
Article
ISSN
0022-3549

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Physiologically based pharmacokinetic mo
✍ Trudy Rodgers; Malcolm Rowland 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 269 KB

A key component of whole body physiologically based pharmacokinetic (WBPBPK) models is the tissue-to-plasma water partition coefficients (Kpu's). The predictability of Kpu values using mechanistically derived equations has been investigated for 7 very weak bases, 20 acids, 4 neutral drugs and 8 zwit