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Rodent models of the human acetylation polymorphism: Comparisons of recombinant acetyltransferases

✍ Scribed by David W Hein; Mark A Doll; Adrian J Fretland; Kevin Gray; Anne C Deitz; Yi Feng; Wen Jiang; Timothy D Rustan; Shelly L Satran; Timothy R Wilkie Sr.

Book ID
114071235
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
160 KB
Volume
376
Category
Article
ISSN
0027-5107

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Effects of single nucleotide polymorphis
Effects of single nucleotide polymorphisms in human N-acetyltransferase 2 on metabolic activation (O-acetylation) of heterocyclic amine carcinogens
✍ David W. Hein; Adrian J. Fretland; Mark A. Doll 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 79 KB

## Abstract N‐Acetyltransferase 2 (NAT2) catalyzes the O‐acetylation of N‐hydroxy heterocyclic amines such as N‐hydroxy‐2‐amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline (NOHMeIQx) and N‐hydroxy‐2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b] pyridine (NOH PhIP) to DNA binding metabolites that initiate mut