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Rodent Models of TDP-43 Proteinopathy: Investigating the Mechanisms of TDP-43-Mediated Neurodegeneration

โœ Scribed by Tania F. Gendron; Leonard Petrucelli


Book ID
107575543
Publisher
Humana Press Inc
Year
2011
Tongue
English
Weight
248 KB
Volume
45
Category
Article
ISSN
0895-8696

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## Abstract Transactive response DNAโ€binding proteinโ€43 (TDPโ€43) neuronal toxicity plays an essential role in the pathogenesis of amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitinโ€positive inclusions. In our previous study, we showed that lowโ€grade overexpression of