𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Rod densitometry in night blindness: A review and two puzzling cases

✍ Scribed by J. E. E. Keunen; G. J. Meel; D. Norren

Book ID
104647086
Publisher
Springer-Verlag
Year
1988
Tongue
English
Weight
743 KB
Volume
68
Category
Article
ISSN
0012-4486

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✦ Synopsis

Since the non-invasive technique of retinal densitometry became available in 1955, rhodopsin kinetics could be studied in vivo. It was obvious that with this new tool investigators focussed attention on the aetiology of night blindness in various diseases. A brief review about the clinical developments in the past two decades is given. Also three case-reports are presented, which suggest that in some cases of congenital stationary night blindness (CSNB) the night blindness might arise from the absence of rhodopsin. This is contrary to the standing opinion and presents problems regarding the integrity of the retina.

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✍ Viktoria Szabo; Hans-JΓΌrgen Kreienkamp; Thomas Rosenberg; Andreas Gal πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 193 KB

Congenital stationary night blindness (CSNB) is a non-progressive Mendelian condition resulting from a functional defect in rod photoreceptors. A small number of unique missense mutations in the genes encoding various members of the rod phototransduction cascade, e.g. rhodopsin (RHO), cGMP phosphodi