Robustness of the maximum-likelihood-binomial approach for linkage analysis of quantitative trait loci with non-normal phenotypic data

The Maximum-Likelihood-Binomial method r

The Maximum-Likelihood-Binomial method revisited: a robust approach for model-free linkage analysis of quantitative traits in large sibships

✍ Aurelie Cobat; Laurent Abel; Alexandre Alcaïs 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 254 KB 👁 2 views

Model-free linkage analysis methods, based on identity-by-descent allele sharing, are commonly used for complex trait analysis. The Maximum-Likelihood-Binomial (MLB) approach, which is based on the hypothesis that parental alleles are binomially distributed among affected sibs, is particularly popul