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Robust Tests for Candidate-Gene Association Using Case-Parents Trios with a Multi-Allelic Marker

✍ Scribed by Gang Zheng; Zehua Chen

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 87 KB
Volume: 46
Category: Article
ISSN: 0323-3847
DOI: 10.1002/bimj.200410057

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✦ Synopsis

Abstract

In case‐parents trios design, the association between a multi‐allelic candidate‐gene and a disease can be detected by using maximum of score tests (max‐score) when the mode of inheritance is known. We apply the maximum of the max‐score statistics and the maximum of likelihood ratio statistics when the genetic model is unknown and examine their robust properties compared to max‐score statistics. The simulation results demonstrate that the two maximum robust tests are more efficacious and robust across all genetic models compared with the three max‐score tests. Moreover, in most situations, the maximum of the max‐score tests seems to be more powerful than the maximum of the likelihood ratio tests. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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## Abstract Markers in five candidate genes were examined on 269 case‐parent trios ascertained through a child with an isolated, non‐syndromic oral cleft (cleft lip, CL; cleft palate, CP; or cleft lip and palate, CLP). Cases and their parents were ascertained through treatment centers in Maryland.