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Robust Synthesis and Crystal-Structure Analysis of 7-Cyano-7-deazaguanine (PreQ0 Base) and 7-(Aminomethyl)-7-deazaguanine (PreQ1 Base)

✍ Scribed by Florian Klepper; Kurt Polborn; Thomas Carell

Book ID: 102261057
Publisher: John Wiley and Sons
Year: 2005
Tongue: German
Weight: 166 KB
Volume: 88
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200590201

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✦ Synopsis

Abstract

We describe robust and efficient synthetic methods for the synthesis of the preQ~0~ and preQ~1~ bases, which are the biosynthetic precursors of the hypermodified RNA nucleoside queuosine. The X‐ray crystal‐structure analysis of preQ~1~ is also described.

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