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Robust design in a two treatment comparison in the presence of a covariate

✍ Scribed by Nancy E. Heckman


Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
396 KB
Volume
16
Category
Article
ISSN
0378-3758

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Unobserved covariates in the two-sample
✍ Philippe BroΓ«t; Thierry Moreau; Joseph Lellouch; Bernard Asselain πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 87 KB πŸ‘ 2 views

In analysing a clinical trial with the logrank test, the hazards between the two groups are usually assumed to be proportional. Nevertheless, this hypothesis is no longer valid with unobserved covariates. As a consequence, there is a loss of power of the logrank test for testing the null hypothesis