✦ LIBER ✦

Robotic deposition of model hydroxyapatite scaffolds with multiple architectures and multiscale porosity for bone tissue engineering

✍ Scribed by Jennifer G. Dellinger; Joseph Cesarano III; Russell D. Jamison

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 618 KB
Volume: 82A
Category: Article
ISSN: 1549-3296
DOI: 10.1002/jbm.a.31072

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✦ Synopsis

Abstract

Model hydroxyapatite (HA) scaffolds with porosities spanning multiple length scales were fabricated by robocasting, a solid freeform fabrication technique based on the robotic deposition of colloidal pastes. Scaffolds of various architectures including periodic, radial, and superlattice structures were constructed. Macropores (100–600 μm) were designed by controlling the arrangement and spacing between rods of HA. Micropores (1–30 μm) and submicron pores (less than 1 μm) were produced within the rods by including polymer microsphere porogens in the HA pastes and by controlling the sintering of the scaffolds. These model scaffolds may be used to systematically study the effects of scaffold porosity on bone ingrowth processes both in vitro and in vivo. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007

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