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RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells

✍ Scribed by P.H. Anderson; G.J. Atkins; D.M. Findlay; P.D. Oloughlin; K. Welldon; C. Vincent; H.A. Morris

Book ID: 116697982
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 223 KB
Volume: 103
Category: Article
ISSN: 0960-0760
DOI: 10.1016/j.jsbmb.2006.12.084

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## Abstract Cultured rodent osteoblastic cells reiterate the phenotypic differentiation and maturation of osteoblasts seen in vivo. As previously shown, the human osteosarcoma cell line HOS 58 represents a differentiated stage of osteoblast development. The potential of HOS 58 for still further in