RNA targeting by small molecule alkaloids: Studies on the binding of berberine and palmatine to polyribonucleotides and comparison to ethidium

Binding of DNA-binding alkaloids berberi

Binding of DNA-binding alkaloids berberine and palmatine to tRNA and comparison to ethidium: Spectroscopic and molecular modeling studies

✍ Md. Maidul Islam; Prateek Pandya; Sebanti Roy Chowdhury; Surat Kumar; Gopinatha 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 870 KB

The interaction of two natural protoberberine plant alkaloids berberine and palmatine with tRNA phe was studied using various biophysical techniques and molecular modeling and the data were compared with the binding of the classical DNA intercalator, ethidium. Circular dichroic studies revealed that