## Abstract The hereditary neurodegenerative disease spinal muscular atrophy (SMA) with childhood onset is one of the most common genetic causes of infant mortality. The disease is characterized by selective loss of spinal cord motor neurons leading to muscle atrophy and is the result of mutations
RNA processing defects associated with diseases of the motor neuron
β Scribed by Stephen J. Kolb; Scott Sutton; Daniel R. Schoenberg
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 195 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0148-639X
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The recognition that both human and murine retroviruses can cause motor neurone diseaselike syndromes has raised the possibility that a retrovirus may be involved in the aetiology of motor neurone disease. This possibility was explored by looking for evidence of reverse transcriptase in the serum of
## Communicated by Francesco Giannelli (NCV) were in the normal range, and there was no finding of nerve conduction block. His younger brother had also been affected by MND. He had developed muscle weakness of the right upper limb at age 52, followed by muscle weakness and atrophy of all limbs, an