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RNA polymerase is poised for activation across the genome

✍ Scribed by Muse, Ginger W; Gilchrist, Daniel A; Nechaev, Sergei; Shah, Ruchir; Parker, Joel S; Grissom, Sherry F; Zeitlinger, Julia; Adelman, Karen

Book ID: 109914248
Publisher: Nature Publishing Group
Year: 2007
Tongue: English
Weight: 425 KB
Volume: 39
Category: Article
ISSN: 1061-4036
DOI: 10.1038/ng.2007.21

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In Xenopus and Drosophila embryos, activation of the zygotic genome occurs after a series of rapid nuclear divisions in which DNA replication occupies most of the cell cycle. In these organisms, it has been proposed that zygotic transcription does not begin until a threshold nucleocytoplasmic ratio