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RNA interference-triggered reversal of ABCC2-dependent cisplatin resistance in human cancer cells

โœ Scribed by Verena Materna; Alexandra Stege; Pawel Surowiak; Axel Priebsch; Hermann Lage


Book ID
116293305
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
207 KB
Volume
348
Category
Article
ISSN
0006-291X

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## Abstract Resistance to platinumโ€containing antineoplastic drugs is the major limitation in their clinical use. To elucidate the role of the ABC transporter MRP2 in platinum drug resistance, its expression was analyzed in human cisplatinโ€resistant cell lines: the ovarian carcinoma line A2780RCIS,