RNA interference: on the road to an alternate therapeutic strategy!

✍ Scribed by Rajnish S. Dave; Roger J. Pomerantz

• Book ID: 104590476
• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 203 KB
• Volume: 13
• Category: Article
• ISSN: 1052-9276
• DOI: 10.1002/rmv.407

✦ Synopsis

Abstract

RNA interference (RNAi) is a newly described natural biological phenomenon mediated by small interfering RNA (siRNA) molecules which target viral mRNA for degradation by cellular enzymes. RNAi has become a method of choice for studying gene function, especially in mammalian systems. With proof‐of‐concept studies already presented against a wide variety of human pathogens and several innovative methods of delivering the siRNA to a wide variety of primary cells available, the role for siRNA as a potential therapeutic strategy is becoming increasingly clear. This review presents recent advances in this direction. Copyright © 2003 John Wiley & Sons, Ltd.