## Abstract Bone morphogenetic proteinβ2 (BMPβ2) plays a key role in osteogenesis. Biomaterials used for the sustained delivery of BMPβ2 __in vivo__ have shown therapeutic benefits. In the present study, BMPβ2 was loaded in porous silk fibroin scaffolds derived from silkworm cocoons (2.4 Β± 0.14 ΞΌg
RNA interference for noggin enhances the biological activity of bone morphogenetic proteins in vivo and in vitro
β Scribed by Kazushi Takayama; Akinobu Suzuki; Tomoya Manaka; Susumu Taguchi; Yusuke Hashimoto; Yuuki Imai; Shigeyuki Wakitani; Kunio Takaoka
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 446 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0914-8779
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Bone morphogenetic protein-2 (BMP-2) has been widely used as an effective growth factor in bone tissue engineering. However, large amounts of BMP-2 are required to induce new bone and the resulting side effects limit its clinical application. Sulfated polysaccharides, such as native heparin, and hep
## Abstract While traditional metabolic engineering generally relies on the augmentation of specific genes and pathways in order to increase the yield of target proteins, the advent of RNA interference (RNAi) as a biological tool has given metabolic engineers another tool capable of rationally alte