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Rituximab treatment of systemic lupus erythematosus in controlled trials and in clinical practice: Two sides of the same coin

✍ Scribed by Fabrizio Conti; Carlo Perricone; Fulvia Ceccarelli; Guido Valesini

Book ID
113482328
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
151 KB
Volume
9
Category
Article
ISSN
1568-9972

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## Abstract ## Objective B cells are likely to contribute to the pathogenesis of systemic lupus erythematosus (SLE), and rituximab induces depletion of B cells. The Exploratory Phase II/III SLE Evaluation of Rituximab (EXPLORER) trial tested the efficacy and safety of rituximab versus placebo in p