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Rituximab in childhood systemic lupus erythematosus refractory to conventional immunosuppression

✍ Scribed by Monika Edelbauer; Therese Jungraithmayr; Lothar Bernd Zimmerhackl


Publisher
Springer
Year
2005
Tongue
English
Weight
157 KB
Volume
20
Category
Article
ISSN
0931-041X

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## Abstract ## Objective B cells are likely to contribute to the pathogenesis of systemic lupus erythematosus (SLE), and rituximab induces depletion of B cells. The Exploratory Phase II/III SLE Evaluation of Rituximab (EXPLORER) trial tested the efficacy and safety of rituximab versus placebo in p