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Risk of significant cytopenias after treatment with tocilizumab in systemic juvenile arthritis patients with a history of macrophage activation syndrome

✍ Scribed by Elizabeth A Kessler, Sheetal S Vora, James W Verbsky

Book ID
119905781
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
198 KB
Volume
10
Category
Article
ISSN
1546-0096

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## Abstract The aberrant induction of proinflammatory cytokines is considered to be crucial in the pathogenesis of systemic juvenile idiopathic arthritis and adult‐onset Still's disease. Interleukin‐18 (IL‐18) in particular has been reported to be a candidate for the key cytokine in both diseases;