It is uncertain whether patients with nonalcoholic fatty liver disease (NAFLD) and normal alanine aminotransferase (ALT) have a milder disease and should undergo liver biopsy. We reviewed the histological data of 458 Italian patients with NAFLD in whom liver biopsy was indicated by altered liver enz
Risk of severe liver disease in NAFLD with normal ALT levels: A pediatric report
โ Scribed by Melania Manco; Anna Alisi; Valerio Nobili
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 61 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
โฆ Synopsis
We appreciated the interest in our article 1 and the insightful comments from Dr. Enzo Emanuele. We believe that routine use of the proposed NASH scoring system, which comprises variables readily available to clinicians when they evaluate morbidly obese patients, can facilitate clinical decisions and help clinicians choose and tailor treatment for morbid obesity, including bariatric surgery. We agree with Dr. Emanuele that many other biomarkers may indeed increase the diagnostic performance of the proposed NASH scoring system. Further clinical translational research, including cost analysis, is needed to better define diagnostic and therapeutic approaches to obesity and its associated diseases.
๐ SIMILAR VOLUMES
We congratulate Fracanzani and colleagues 1 on their insightful article identifying factors associated with severe liver disease in patients with nonalcoholic fatty liver disease (NAFLD) and normal aminotransferase levels. First, the authors have convincingly demonstrated that normal alanine aminotr