✦ LIBER ✦

Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis

✍ Scribed by Michael H. Weisman; Daniel E. Furst; Grace S. Park; Joel M. Kremer; Katie M. Smith; Daniel J. Wallace; Jacques R. Caldwell; Thierry Dervieux

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 89 KB
Volume: 54
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.21573

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Pharmacogenomic and metabolic biomarkers

Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis

✍ Thierry Dervieux; Neal Greenstein; Joel Kremer 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 166 KB

## Abstract ## Objective To evaluate the contribution of metabolites (methotrexate [MTX] and folate polyglutamate [PG] levels) and pharmacogenetic biomarkers in the folate pathway to the effects of MTX in patients with rheumatoid arthritis not previously treated with this antifolate. ## Methods

Efficacy and toxicity of methotrexate in

Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes

✍ Judith A. M. Wessels; Jeska K. de Vries-Bouwstra; Bas T. Heijmans; P. Eline Slag 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 97 KB 👁 2 views

Polyglutamation of methotrexate with com

Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis

✍ Thierry Dervieux; Daniel Furst; Diana Orentas Lein; Robert Capps; Katie Smith; M 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB 👁 2 views

## Abstract ## Objective Methotrexate (MTX) enters cells through the reduced folate carrier (RFC‐1) and exerts part of its effects through polyglutamation to MTX polyglutamates (MTXPGs) and inhibition of 5‐aminoimidazole‐4‐carboxamide ribonucleotide transformylase (ATIC) and thymidylate synthase (