𝔖 Bobbio Scriptorium
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Risk for dementia and age at measurement

✍ Scribed by Hannah A. D. Keage; Saurabh Gupta; Carol Brayne; On behalf of the Alzheimer's Society Systematic Review Group

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
76 KB
Volume
26
Category
Article
ISSN
0885-6230

No coin nor oath required. For personal study only.

✦ Synopsis

longer significantly associated with treatment discontinuation.

Discussion

In our study we found that cardiovascular side effects were rarely a reason for discontinuation of the medication. Furthermore the two patients whose treatments were discontinued due to probable cardiovascular side effect had a normal pre-treatment ECG.

Our study shows that for patients prescribed AChEIs, ECGs were not a useful risk reduction tool to identify cardiovascular side effects in individuals. We cannot comment on the number of patients who were precluded from being prescribed AChEIs due to pretreatment ECG abnormalities.

We would agree with Maliepaard and MacEwan (2009) that locally agreed protocols would be helpful. In these protocols a balance needs to be agreed between the prevention of over investigation and the prevention of possible serious side effects. Although ECGs do not appear valuable in predicting cardiovascular side effects, in our opinion the place of ECGs should be seen in the wider context of assessment in memory clinic.

References

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