✦ LIBER ✦

Risk factors for thrombosis in nonembolic cerebrovascular disease

✍ Scribed by Mohanty, Sujata; Saxena, Renu; Behari, Madhuri

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 20 KB
Volume: 60
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(199903)60:3<239::aid-ajh14>3.0.co;2-9

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✦ Synopsis

Thirty-seven young patients (less than 42 years of age) presenting with sudden onset of idiopathic nonembolic cerebrovascular disease were evaluated for underlying prothrombotic factors. Activated protein C resistance (APC-R) was measured by Dahlback's method and the modified method using factor V-deficient plasma. Activities of antithrombin (AT) III, protein C and S were measured. Anticardiolipin antibody was estimated by ELISA and lupus anticoagulant by kaolin clotting tests.

APC-R was the most common defect (21.62%) followed by AT III deficiency and presence of anticardiolipin antibodies (5.6% each). The latter two were present together in one case. It is thus concluded that APC-R is the most common defect underlying idiopathic nonembolic cerebrovascular infarction in young individuals. Am.

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