𝔖 Bobbio Scriptorium
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Risk factors for hepatocellular carcinoma in catalonia, spain

✍ Scribed by M Vall Mayans; X. Calvet; J. Bruix; M. Bruguera; J. Costa; J. Estève; F. X. Bosch; C. Bru; J. Rodés

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
544 KB
Volume
46
Category
Article
ISSN
0020-7136

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✦ Synopsis

The influence of hepatitis B virus infection, alcohol consumption, tobacco smoking and use of oral contraceptives on the risk of hepatocellular carcinoma (HCC) was evaluated in a hospital-based case-control study in Catalonia, in the Mediterranean coastal area of north-eastern Spain. A total of 96 HCC cases (86.5% of them with associated liver cirrhosis) and 190 age-and sex-matched controls were studied. The odds ratio of HCC and 95% confidence interval among hepatitis B surface antigen (HBsAg) carriers was 4.9 ( I 3-21.9). The O R was not significantly elevated in smokers, and a marginally significant increased risk was found among users of oral contraceptives based on 6 female cases. There was a significant dose-response relationship between alcohol consumption and risk of HCC (x' for trend: 24.3, p < 0.001). Although hepatitis 6 infection was strongly associated with HCC, alcohol abuse leading to cirrhosis appears to be one of the main causes of HCC in this region. ~ 3Present address: International Agency for Research on Cancer, YO MRC Laboratories, P.O. Box 273 Banjul, The Gambia. 4 T ~ whom reprint requests should be addressed.

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