✦ LIBER ✦

Risk factors for developing synchronous esophageal neoplasia in patients with head and neck cancer

✍ Scribed by Wen-Lun Wang; Ching-Tai Lee; Yi-Chia Lee; Tzer-Zen Hwang; Chih-Chun Wang; Jau-Chung Hwang; Chi-Ming Tai; Chi-Yang Chang; Shang-Shyue Tsai; Cheng-Ping Wang; Jenq-Yuh Ko; Jaw-Town Lin

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 85 KB
Volume: 33
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21397

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

This study investigated the risk factors for synchronous esophageal neoplasia in patients with head and neck squamous cell carcinoma (HNSCC).

Methods

All 315 consecutive patients with newly diagnosed HNSCC received endoscopic esophageal screening with image‐enhanced endoscopy.

Results

Sixty‐nine patients (21.9%) had synchronous esophageal neoplasia, 37 (53.6%) with superficial neoplasia and 21 (30.4%) with multiple esophageal lesions. Univariate analysis revealed age <50 years, drinking alcohol, and location of index HNSCC were significant risk factors for developing synchronous esophageal neoplasia. In multivariate analysis, drinking alcohol (odds ratio [OR], 3.792; p = .0035), index oropharynxgeal cancers (OR, 3.618; p = .0045) and hypopharyngeal cancers (OR, 2.627; p = .0029) were independent risk factors. Drinking alcohol was clearly dose–response related (p = .001).

Conclusion

Alcohol consumption and index tumor location are associated with the development of synchronous esophageal neoplasia in patients with HNSCC. Because of the high prevalence, routine endoscopic examination of the esophagus should be recommended, especially in patients with the risk factors identified. © 2010 Wiley Periodicals, Inc. Head Neck, 2011

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