Rise in intracellular calcium concentration by propylene glycol-induced hypertonicity in PC12 cells

✍ Scribed by Toshimi Hattori; Toshiko Miyazawa

• Book ID: 102962371
• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 686 KB
• Volume: 31
• Category: Article
• ISSN: 0893-6609
• DOI: 10.1002/nrc.10036

✦ Synopsis

Abstract

There are some reports that clinical application of propylene glycol (PG) induces hypertonicity and results in various toxicities. In our experiments, a hypertonic solution made by adding PG to a normal saline raised the intracellular calcium concentration ([Ca^2+^]i). The present study was conducted with the object of determining whether hypertonicity is related to the rise in [Ca^2+^]i induced by PG. Hypertonic salines made by adding PG, NaCl, sucrose, mannitol or glucose to a normal saline raised the [Ca^2+^]i. The isotonic PG saline concentration‐dependently decreased the [Ca^2+^]i. Isotonic salines containing sucrose, glucose or mannitol raised the [Ca^2+^]i. The findings obtained lead us to the conclusion that PG raises the [Ca^2+^]i by elevating the tonicity of the saline.