Ring-opening of N-alkoxycarbonyl γ-lactams with lithium methylphenylsulphone: application to the synthesis of cis 2,5-disubstituted pyrrolidines

✍ Scribed by Antonio J. Mota; Nicole Langlois

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 174 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02839-3

✦ Synopsis

The ring-opening of N-alkoxycarbonyl g-lactams with lithium methylphenyl sulphone was studied and applied to the synthesis of enantiopure cis 2,5-disubstituted pyrrolidines