Ring Opening of Aziridines by Aromatic Thiols Followed by Amino-Substitution.
โ Scribed by Truls Ingebrigtsen; Tore Lejon
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 15 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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โฆ Synopsis
Abstract
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๐ SIMILAR VOLUMES
Various enantiomerically pure aziridine-2-methanol derivatives 3a-I were reacted with thiophenol in methylene chloride at room temperature to obtain ring-opening products 4a-I in high yields with excellent regioselectivity. The reaction procedure is very simple and it provides highly functionalized
Preparation of Cysteinol Derivatives by Highly Regioselective Ring Opening of Nonactivated Chiral Aziridines by Thiols. -Ring opening reactions of nonactivated aziridines (I) (12 examples) with thiols, e.g. (II) and (IV), proceed with high regioselectivity and generate chiral cysteinol derivatives (