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Ring formation and structural rearrangements of chromosome 1 as secondary changes in uterine leiomyomas with t(12;14)(q14–15;q23–24)

✍ Scribed by Mef Nilbert; Sverre Heim; Nils Mandahl; Ulla-Maria Flodérus; Helena Willén; Måns Åkerman; Felix Mitelman

Book ID
119103871
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
525 KB
Volume
36
Category
Article
ISSN
0165-4608

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Uterine leiomyoma is the most common tumor of smooth muscle cell origin and is often associated with the recurrent balanced translocation t( 12; I4)(q I 3-I5;q24). As an initial step toward finding the gene or genes that are interrupted by the translocation breakpoint, a somatic cell hybrid carrying