Ring expansion in the coupling of Fischer-carbene complexes with 1-alkynyl-1-hydroxy cyclic compounds
β Scribed by Metin Zora; James W Herndon; Yuhui Li; Jason Rossi
- Book ID
- 108371201
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 276 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0040-4020
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AbstractΓA synthetic route to taxol and other Taxus diterpenes is described which employs as a key step the reaction between a Fischer carbene complex and a 1,6 enyne to construct 1-substituted-7,7-dimethyl-2-methylenebicyclo[3.1.1]heptan-6-ones. It was found that the reaction between complex 2 and
## Abstract We examined the reactivity of dimethylaminodiazafulvene **1** toward Fischer alkenylcarbene **2** and alkynylcarbene **3** complexes. Diazafulvene **1** reacts with alkenylcarbenes **2** through a formal [6+3] heterocyclization in a regioβ and stereoselective manner to afford dihydroimi