Ring closures via the Wurtz reaction a convenient synthesis of cyclobutane

✍ Scribed by Daniel S. Connor; Eugene R. Wilson

• Publisher: Elsevier Science
• Year: 1967
• Tongue: French
• Weight: 242 KB
• Volume: 8
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)89939-1

✦ Synopsis

Although the Wurtz reaction has previously been used in the synthesis of a few alicyclic compounds, practical considerations such as yields, accessibility of starting materials, and the availability of good alternative routes have severely limited its use. Indeed, its utility has been almost exclusively limited to the closures of three membered rings, the best example being the synthesis of cyclopropane in greater than 80$ yield (1). Other examples include the syn-