✦ LIBER ✦
Ring closing metathesis in organic synthesis: Evolution of a high speed, solid phase method for the preparation of β-turn mimetics
✍ Scribed by Anthony D Piscopio; John F Miller; Kevin Koch
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 573 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
✦ Synopsis
Complimentary solid phase syntheses of the Freidinger lactam class of 13-turn mimetics have been developed using ring closing metathesis as both the key carbon-carbon bond forming step and the cyclative cleavage mechanism. Solid phase variants of the Fukuyarna-Mitsunobu proce/ss were utilized as part of a rapid three-step sequence to construct immobilized lactarn precursors. An alternative solid phase process is offered which utilizes an Ugi/ring closing metathesis reaction tandem to deliver the desired compounds in two synthetic operations.