✦ LIBER ✦

Ring-chain tautomerism in 2,2-bis(2-thienyl)tetrahydrofurans: preparation of [butene-2H5]-tiagabine

✍ Scribed by John M. Herbert; Trevor W. Mathers

Publisher: John Wiley and Sons
Year: 2010
Tongue: French
Weight: 98 KB
Volume: 53
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1787

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A concise preparation of [butene‐^2^H~5~]‐tiagabine hydrochloride starting from [^2^H~6~]‐γ‐butyrolactone is described. It was necessary to ring‐open the labeled γ‐butyrolactone precursor before the addition of 2‐thienyllithium to avoid cyclisation of the intermediate to a 2,2‐bis(2‐thienyl)tetrahydrofuran. Copyright © 2010 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Stereoisomerism and Ring-Chain Tautomeri

Stereoisomerism and Ring-Chain Tautomerism in 1-Hydroxy-2,3-dihydro-1H-pyrazolo[1,2-a]pyridazine-5,8-diones and 1-Hydroxy- and 1-Amino-2,3-dihydro-1H-pyrazolo[1,2-b]phthalazine-5,10-diones

✍ Jari Sinkkonen; Vladimir Ovcharenko; Kirill N. Zelenin; Irina P. Bezhan; Boris A 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 154 KB 👁 1 views

1H and 13C NMR Study of 1-Hydrazino-2,3-

1H and 13C NMR Study of 1-Hydrazino-2,3-dihydro-1H-pyrazolo[1,2-a]pyridazine-5,8-diones and -1H-pyrazolo[1,2-b]phthalazine-5,10-diones and Their Ring-Chain Tautomerism

✍ Jari Sinkkonen; Vladimir Ovcharenko; Kirill N. Zelenin; Irina P. Bezhan; Boris A 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 135 KB 👁 1 views