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Riluzole therapy in cervical dystonia

✍ Scribed by Jörg Müller; Gregor K. Wenning; Jörg Wissel; Angelika Baldauf; Klaus Seppi; Christian Brenneis; Werner Poewe

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 511 KB
Volume: 17
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.1200

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✦ Synopsis

Abstract

We conducted a 6‐week open‐label pilot study with blinded video rating of riluzole (50 mg twice a day) in six patients with cervical dystonia (CD) refractory to botulinum toxin A and oral pharmacological treatment. The Tsui rating scale served as primary efficacy measure and improved significantly under riluzole (P = 0.002). In three of six patients, the Tsui score improved by more than 30% with a greater 50% reduction in the head tremor/jerk subscore of the Tsui scale. These data suggest that riluzole may be helpful in a subgroup of patients with disabling CD refractory to other therapies. © 2001 Movement Disorder Society.

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