Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy)

Loss of dopaminergic responsiveness in a

Loss of dopaminergic responsiveness in a double lesion rat model of the Parkinson variant of multiple system atrophy

✍ Martin Köllensperger; Nadia Stefanova; Markus Reindl; Werner Poewe; Gregor K. We 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 107 KB

## Abstract The Parkinson variant of multiple system atrophy (MSA‐P) is a distinct atypical parkinsonian disorder with a loss of dopaminergic neurons comparable to that found in Parkinson's disease (PD). The additional loss of striatopallidal projections is thought to account for levodopa unrespons