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Riluzole (2-amino-6-trifluoromethoxy benzothiazole) attenuates MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice

✍ Scribed by Tsutomu Araki; Yasuko Muramatsu; Katsuyuki Tanaka; Mitsunobu Matsubara; Yutaka Imai

Book ID: 117472075
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 263 KB
Volume: 312
Category: Article
ISSN: 0304-3940
DOI: 10.1016/s0304-3940(01)02176-0

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP