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Rigidity of fibrin gels as measured by quasielastic light scattering

✍ Scribed by R. A. Gelman; J. A. Gladner; R. Nossal

Publisher
Wiley (John Wiley & Sons)
Year
1980
Tongue
English
Weight
729 KB
Volume
19
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

The strength of fibrin gels has been investigated by a recently developed laser light scattering technique for determining the shear modulus of soft gels. By this method, changes in the modulus were monitored as a function of time without perturbing the material. Fibrin gels were crosslinked with blood coagulation factor XIII. Rigidity measurements and SDS–polyacrylamide gel electrophoresis were used to correlate gel strength with the number of covalently bonded subunit chains. The modulus was found to vary linearly with the number of crosslinks until maximum rigidity was achieved.

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