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Rigid structural requirement of the 5′ terminus of mRNA for translational activity

✍ Scribed by Manchanahalli S. Rao; Benjamin C. Wu; Jeffrey Waxman; Harris Busch

Book ID
118310120
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
419 KB
Volume
66
Category
Article
ISSN
0006-291X

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We have determined that the peptide lipocortin-5 N-terminus (LIPO-5NT) was able to inhibit rabbit platelet aggregation in a concentration-and time-dependent manner. In order to assess which residues in LIPO-5NT were essential for its activity, an 'Ala-scan' was performed by sequentially substituting