The hammerhead ribozyme is an intriguing RNA molecule with the ability to serve as a catalyst to cleave sequence-specifically RNA molecules in an intermolecular reaction. Preferentially Mg 2Ο© is required for optimal activity by inducing the catalytically competent conformation and by possibly acting
β¦ LIBER β¦
Ribozymes: The hammerhead swings into action
β Scribed by Jennifer A Doudna
- Book ID
- 114321232
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 132 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0960-9822
No coin nor oath required. For personal study only.
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Elucidation of the catalytic mechanism and structure-function relationship studies of the hammerhead ribozyme continue to be an area of intensive research. A combination of diverse approaches, such as X ray crystallography, spectral studies, chemical modifications, sequence variations and kinetic an