Ribozymes
โ Scribed by John J. Rossi
- Book ID
- 103978455
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 538 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0958-1669
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โฆ Synopsis
RNA enzymes or ribozymes are receiving considerable attention for their potential use as highly specific inhibitors of gene expression. From the basic science perspective, the mechanisms by which ribozymes catalyze site-specific cleavage (and in some cases ligation) reactions provide exciting and active areas of scientific investigation. The most recent developments in our understanding of the molecular mechanisms of catalysis, as well as in vivo applications of ribozymes, are highlighted.
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In this review I will outline several chemogenetic approaches used to determine the chemical basis of large ribozyme function and structure. The term chemogenetics was first used to describe site-specific functional group modification experiments in the analysis of DNA-protein interactions. Within t