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Ribozyme-Mediated Induction of Apoptosis in Human Cancer Cells by Targeted Repair of Mutant p53 RNA

✍ Scribed by SHIN, K

Book ID
120049204
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
514 KB
Volume
10
Category
Article
ISSN
1525-0016

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## Abstract Stress protein mortalin (mtHSP70) is highly expressed in cancer cells. It was shown to contribute to carcinogenesis by sequestrating the wild type p53, a key tumor suppressor protein, in the cytoplasm resulting in an abrogation of its transcriptional activation function. We have found t