Proliferation of IL-6-independent multip
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Bin Zhang; Robert G. Fenton
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Article
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2002
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John Wiley and Sons
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English
β 484 KB
The evolutionarily conserved Ras/Raf/MEK/ERK pathway is thought to be essential for proliferation of eukaryotic cells. The human multiple myeloma (MM) cell line 8226 encodes an activated K-ras allele and proliferates without requirement for the main MM growth and survival factor IL-6. Surprisingly,