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Ribonuclease-Activated Cancer Prodrug

✍ Scribed by Ellis, Gregory A.; McGrath, Nicholas A.; Palte, Michael J.; Raines, Ronald T.


Book ID
120432063
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
728 KB
Volume
3
Category
Article
ISSN
1948-5875

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Among the broad array of genes that have been evaluated for tumor therapy, those encoding prodrug activation enzymes are especially appealing as they directly complement ongoing clinical chemotherapeutic regimes. These enzymes can activate prodrugs that have low inherent toxicity using both bacteria