Wnt signaling is required for thymocyte
โ
Frank J. T. Staal; Jan Meeldijk; Petra Moerer; Philippe Jay; Barbara C. M. van d
๐
Article
๐
2001
๐
John Wiley and Sons
๐
English
โ 171 KB
T cell factor/lymphocyte enhancer factor (Tcf/Lef) transcription factors complex with the transcriptional co-activator g -catenin to transduce Wnt signals in a variety of developmental systems. The prototypic family member Tcf-1 is highly expressed in T lineage cells. Tcf1 -/- mice are defective in