Rhodium-hydroxyl bisphospholane catalyzed highly enantioselective hydrogenation of dehydroamino acids and esters

✍ Scribed by Wenge Li; Zhaoguo Zhang; Dengming Xiao; Xumu Zhang

• Book ID: 104262037
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 220 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)01254-x

✦ Synopsis

A chiral hydroxyl bisphospholane, 1,2-bis [(2S,3S,4S,5S)-3,4-dihydroxyl-2,5-dimethylphospholanyl]benzene (4), was synthesized from readily available D-mannitol. Its Rh(I) complex catalyzes asymmetric hydrogenation of dehydroamino acids and their ester derivatives with excellent enantioselectivities (98 to >99% ee).