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Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to β-Phthaliminoacrylate Esters toward the Synthesis of β-Amino Acids

✍ Scribed by Nishimura, Takahiro; Wang, Jun; Nagaosa, Makoto; Okamoto, Kazuhiro; Shintani, Ryo; Kwong, Fuk-yee; Yu, Wing-yiu; Chan, Albert S. C.; Hayashi, Tamio


Book ID
126403020
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
167 KB
Volume
132
Category
Article
ISSN
0002-7863

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Efficient Rh-catalyzed asymmetric 1,4-addition of arylboronic acids to ethyl-c-phthalimidocrotonate by using bis-sulfoxide ligand affords c-aminobutyric acid (GABA) derivatives with high enantioselectivities (90-96% ee) under mild conditions. Optically pure (S)-Baclofen and (S)-Rolipram have been pr